Zero Tension Mouse

Looking more like a joystick, this USB mouse features the basic functions (scroll wheel, right/left mouse buttons), digital optical tracking, and comes in medium/large sizes. It measures 4.5 x 3.4 x 5.6 in. and is compatible with MAC/PC computers.

Soap – The Mid-Air Mouse

Soap puts a new twist on tradional optical mice by adding mid-air functionality. This technology is “based on hardware found in a mouse” and “consists of an optical sensor device moving freely inside a hull made of fabric.” Video demonstration after the jump.

Mario Bros Computer Mice

Available in either Mario or Goomba characters, these mice feature a 400dpi mechanical ball, USB support, and are compatible with Windows/Mac systems.

Mus2 Cursor Mouse

Breaking completely from the typical design for computer mice, Art. Lebedev’s Mus2 is unique to say the least. This cursor-shaped optical mouse has 800 dpi optical sensor resolution, up to 2300 fps frame speed, and is compatible with all Windows/Mac OS X systems.

The Minty Optical Mouse

To make your own “Minty Mouse”, you’ll need one Altoids tin, an optical mouse, dremel tools, epoxy glue, a mini-hack saw, and around 4 hours of free time.

NES Controller Optical Mouse

Most optical mice are boring, not this one. To make your own, you’ll need an NES controller, optical mouse, dremel tool, lots of glue, soldering gun, and four-five hours.

AMG Helmet Optical Mouse

SolidAlliance Japan presents an innovative new wireless optical mouse with a design inspired by Jean Alesi’s AMG-Mercedes Helmet.

Powerglove Mouse

Zerosign managed to convert an old Nintendo Powerglove into a fully functioning computer mouse after countless hours of wiring and hacking.

CP-1 USB Spy Mouse

Keep a close ear on your computer with the CP-1. Hidden inside this otherwise normal looking mouse is a condenser microphone – capable of picking up on any nearby conversations. It measures 53 x 95 x 35 mm and weighs just 75g.
 
Foot Mouse
 Put simply, the Foot Mouse is the strangest we’ve seen. One pedal controls movement while the other is for the clicks. Pedals are made from an injection molded plastic shell and feature a “360-degree, pressure sensitive mechanism”.